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Initial validation of zygosity determination questionnaire for Sri Lankan twins using STR analysis of 15 unlinked loci and the gender-determining marker amelogenin

08/27/2018 00:00:00

Abstract

Genetics

AcademicGenetics

Warnakula, L., Cooray, R., Hapuarachchi, N.S., Jayaweera, K., & Sumathipala, A.

Shifting focus from diseases to patients: Today’s vision, tomorrow’s reality, 131st Anniversary International Medical Congress, Sri Lanka Medical Association, Colombo, Sri Lanka.

Initial validation of zygosity determination questionnaire for Sri Lankan twins using STR analysis of 15 unlinked loci and the gender-determining marker amelogenin

Introduction & Objectives Zygosity determination is an essential component in behavioural genetics which uses twins for research. Although genetic markers are considered gold-standard, questionnaire based methods are preferred in resource poor settings due to cost effectiveness. The present study examines the validity of an adapted Sinhala version of a zygosity determination questionnaire using a panel of 16 Short Tandem Repeats (STRs).

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